J
John Larkin
Guest
On Wed, 25 Oct 2006 03:07:31 GMT, <lucasea@sbcglobal.net> wrote:
us kidneys and eyeballs and brains, it's surely enough to fine-tune
the hardware of evolution itself.
mutations are too destructive, so repair mechanisms evolve to optimize
the mutation rate. Evolution begins to manage itself. The optimum
"crude" mutation rate, the rate of gross random damage to DNA by means
of radiation and such, may well be zero. There are better ways to
shuffle cards than by blasting the deck with a shotgun.
evolve better will, err, evolve better, won't they? You can't argue
with that sort of reasoning.
environment. A few cold winters, or a few millenia of ice age, should
not make us adapt too well to cold if the adaptation will kill us when
it gets warm.
mutation rate increases in times of stress. That would be another
self-optimization: take risks when necessary. There are potentially
many more.
If you believe in evolution, it seems to me that you must believe that
evolution works to optimize the mechanisms of evolution itself, rather
than sticking to the passive random mutation/selection model. It
further seems to me that that course is imperative as long as it's not
physically impossible, and so long as it has adaptive advantages.
I believe in evolution.
tried.
John
Mutation and natural selection, of course. If that was enough to give"John Larkin" <jjlarkin@highNOTlandTHIStechnologyPART.com> wrote in message
news:3g2tj2lhua1fap95hmds1gr987qu2vo90f@4ax.com...
My only real suggestion here has been that evolution should be able to
optimize evolution itself: evolution evolves. And the implications of
that are manifold, and lead to some ideas that produce some
interestingly hostile reactions.
Interesting thought. My first response is to ask what you propose as the
mechanism for that.
us kidneys and eyeballs and brains, it's surely enough to fine-tune
the hardware of evolution itself.
Circular argument. Try imagining.Evolution is so passive, that it's hard to imagine any
form of active control.
Yes, that's basic. The natural mutation rate is too high, and mostThere are two possible points of control that I
see--the mutation rate, and the survivability advantage due to any
particular mutation. As I understand it, mutations are based on 3 general
chemistries: 1) photochemistry of nucleobases, 2) O2 (and other
free-radical) chemistry of nucleobases, and 3) simple mis-transcription. I
do not know in what proportions these mix. It's not clear how the first two
can be manipulated without a sweeping change, for example to other
nucleobases besides ACGT. All three are subject to repair mechanisms in the
body of the lifeform, and this might be one point of active control over the
rate of evolution.
mutations are too destructive, so repair mechanisms evolve to optimize
the mutation rate. Evolution begins to manage itself. The optimum
"crude" mutation rate, the rate of gross random damage to DNA by means
of radiation and such, may well be zero. There are better ways to
shuffle cards than by blasting the deck with a shotgun.
That definition is dogma. DNA may have better ideas. Species thatFinally, it's not clear how evolution would exert any
control over the survivability advantage of a particular mutation, since the
mutations are supposed to be, by definition, random.
evolve better will, err, evolve better, won't they? You can't argue
with that sort of reasoning.
It may also be that evolution should lowpass filter the selectionHowever, it is possible that evolution has already selected for some sort of
optimum rate of evolution. Considering there are probably billions of
mutations for every one mutation that is "productive", and considering that
a mutation probably has a far, far greater chance of causing damage than
good, there will be a limit to how fast productive mutations can crop up,
without having so many catastrophic mutations that the species simply cannot
survive. If an organism mutates at too rapid a rate, it simply won't even
survive one generation because it will likely encounter so many destructive
mutations. This may be how we have evolved a DNA repair mechanism, and the
evolved need to have some rate of uncorrected mutations may have set limits
on the effectiveness of that repair mechanism. This then sets an upper
limit on the rate of "productive evolution".
environment. A few cold winters, or a few millenia of ice age, should
not make us adapt too well to cold if the adaptation will kill us when
it gets warm.
I think there is some evidence, at least in bacteria, that theIn order to assess this
against the actual rate of evolution, it would take some serious attempts at
estimating the productive mutation-to-total mutation ratio, as well as the
destructive mutation-to-total mutation ratio. Both of these would probably
also have to take account of the *degree* of constructiveness or
destructiveness of a particular mutation--so that a mutation that instantly
kills the organism is counted as being far more influential than one that
slightly decreases the chances that an offspring several generations hence
will reach child-rearing age. Considering, however, that I believe current
thought is that evolution happens by punctuated equilibrium, it would be
difficult to assess the long-term average rate of productive mutations to
assess any such attempt to quantitate the "maximum plausible rate of
evolution."
mutation rate increases in times of stress. That would be another
self-optimization: take risks when necessary. There are potentially
many more.
If you believe in evolution, it seems to me that you must believe that
evolution works to optimize the mechanisms of evolution itself, rather
than sticking to the passive random mutation/selection model. It
further seems to me that that course is imperative as long as it's not
physically impossible, and so long as it has adaptive advantages.
I believe in evolution.
Thank you for thinking with me. This is the first time anyone here hasAnyway, it is an interesting thought, and one that I have not heard
biologists address.
tried.
John